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Ambien, with a generic name of Zolpidem is a sedative, also called a hypnotic. It affects chemicals in the brain that may become unbalanced and cause sleep problems (insomnia). Difficulty sleeping could be caused by anxiety, pain, and behaviors such as having naps during the day, depression, psychiatric disorders and even other drugs (e.g. anorectics, caffeine, pseudoephedrine). This medication causes relaxation to help you fall asleep. It has been shown to put patients to sleep more rapidly and keep them asleep longer. The use of sleep medications generally does not exceed 10 days and is taken intermittently to avoid addiction, loss of effectiveness and rebound phenomena.
Subunit modulation of the GABA receptor complex is hypothesized to be responsible for sedative, anticonvulsant, anxiolytic and myorelaxant drug properties. To induce sleep in clients, Ambien acts by binding to the benzodiazepine receptors which is the major modulatory site of the GABA receptor complex. It has a selective affinity to BZD receptors prevalent in the cerebellum (omega-1 receptors). It also has strong sedative actions making it very suitable as a sleep medicine with only minor anxiolytic properties. In addition, it has fewer effects on skeletal muscle and seizure threshold which makes it irreplaceable for benzodiazepines.
Adverse effects are daytime drowsiness, dizziness, lightheadedness, constipation, diarrhea, and dry mouth. It can also cause memory loss. Serious side effects include palpitation, unusual tiredness, new or worsening depression, mental/mood changes, unsteadiness. One serous side effect is chest pain, which is very uncommon. Symptoms of a serious allergic reaction may also occur including rash, itching, swelling, severe dizziness, and trouble breathing.
There is increased sedation with haloperidol and alcohol accompanied by increased sedation and in coordination when taken with tricyclic anti-depressants (TCA). And a reduced effect of hypnosis with rifampicin. It is necessary that prior to prescription of the drug, the physician is made aware of all the other drugs taken with special considerations on other drugs taken that may cause drowsiness.
The effectiveness of the drug lessens when taken right after eating. Ambien should not be taken if the client drinks alcohol. It should be taken exactly as prescribed and right before going to bed so as to prevent accidents. Do not give Ambien unless the client can stay in bed for 7-8 hours. Advise the client not to drive or operate machines after taking Ambien unless they feel fully awake.